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Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
Published on: September 6, 2024
The development of autism spectrum disorders: variability and causal complexity
Robert H Wozniak1,2, Nina B Leezenbaum2, Jessie B Northrup2
1Department of Psychology, Bryn Mawr College, Bryn Mawr, PA, USA.
Abstract:
The autism spectrum is highly variable, both behaviorally and neurodevelopmentally. Broadly speaking, four related factors contribute to this variability: (1) genetic processes, (2) environmental events, (3) gene × environment interactions, and (4) developmental factors. Given the complexity of the relevant processes, it appears unlikely that autism spectrum atypicalities can be attributed to any one causal mechanism. Rather, the development of neural atypicality reflects an interaction of genetic and environmental risk factors. As the individual grows, changes in neural atypicality, consequent variation in behavior, and environmental response to that behavior may become linked in a positive feedback loop that amplifies deviations from the typical developmental pattern. WIREs Cogn Sci 2017, 8:e1426. doi: 10.1002/wcs.1426 For further resources related to this article, please visit the WIREs website.
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