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Isolation and characterization of an antitumor active agar-type polysaccharide of Gracilaria dominguensis
L E Fernández1, O G Valiente, V Mainardi
1Departamento de Bioquímica, Instituto Nacional de Oncología y Radiobiología, Havana, Cuba.
Carbohydrate Research
|July 1, 1989
Abstract:
Cold water extraction of the red alga Gracilaria dominguensis, followed by cetyltrimethylammonium bromide fractionation, gave a highly sulfated, agar-type polysaccharide which inhibited the transplantation of Ehrlich ascites carcinoma in mice. The structure of the polysaccharide has been investigated by methylation analysis, and 1H- and 13C-n.m.r. spectroscopy, and was shown to be mainly composed of alternating (1----3)-linked beta-D-galactopyranosyl 6-sulfate and (1----4)-linked 3,6-anhydro-alpha-L-galactopyranosyl residues.