[Changes in the expression of class I HLA antigens in patients with blood disorders]

In 146 patients with haematological diseases changes in the assessment of HLA antigens after repeated examinations were investigated. In 68.49% of the specimens all HLA antigens were assessed correctly, 8.9% had antigen losses and 22.6% responded by a polyreactive reaction. Changes of the HLA expressivity in the sense of loss or polyreactivity during repeated examinations were followed up and possible causes of changes of HLA expression are discussed.