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Related Concept Videos

Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

323
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
323
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

340
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
340
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

259
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
259
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

578
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
578
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.3K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
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Related Experiment Video

Updated: Mar 11, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Obesity and Prostate Cancer.

Yin Cao1,2, Edward Giovannucci3,4,5

  • 1Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|December 3, 2016
PubMed
Summary

Obesity is linked to a higher risk of aggressive prostate cancer, but the overall relationship is complex due to detection factors like PSA screening. Further research into body fatness and weight change is needed for better interventions.

Keywords:
HeterogenityObesityProstate cancerProstate-specific antigen screening

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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Area of Science:

  • Oncology
  • Epidemiology
  • Metabolic research

Background:

  • Prostate cancer is a complex disease with varied manifestations, influenced by detection methods like prostate-specific antigen (PSA) screening.
  • The relationship between obesity, often measured by body mass index (BMI), and overall prostate cancer risk is inconsistent.
  • Obesity is consistently associated with an increased risk of aggressive prostate cancer, defined by advanced stage, fatality, or poorer prognosis.

Purpose of the Study:

  • To explore the complex relationship between obesity and prostate cancer risk, particularly aggressive forms.
  • To highlight methodological challenges in prostate cancer research, including PSA screening, detection bias, and treatment effects.
  • To investigate potential biological mechanisms linking obesity to prostate cancer and identify areas for future research.

Main Methods:

  • Review of existing etiological and prognostic research on obesity and prostate cancer.
  • Consideration of methodological issues such as PSA screening, detection bias, and treatment.
  • Exploration of potential biological pathways including insulin/IGF axis, sex hormones, and metabolic alterations.

Main Results:

  • Mixed findings regarding obesity and total prostate cancer risk.
  • Consistent association between obesity and higher risk of aggressive prostate cancer.
  • Ongoing investigation into biological mechanisms and the role of molecular subtypes.

Conclusions:

  • A simple summary of obesity's impact on prostate cancer is not feasible due to disease heterogeneity and detection factors.
  • Methodological rigor is crucial for future research on obesity and prostate cancer.
  • Further evaluation of body fatness and weight change across the life course is necessary for understanding mechanisms and developing interventions.