Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hypertrophic scar formation after skin injury.

Journal of wound care·2016

Same author

Salmonella septicaemia in a patient with burns.

Journal of wound care·2016

Same author

Examining first aid received by burn and scald patients.

Journal of wound care·2016

Same author

The effects of exogenous substrate on the metabolism of phosphorylcholine and phosphorylethanolamine by skin.

The Journal of investigative dermatology·2015

Same author

Revised estimates of mortality from burns in the last 20 years at the Birmingham Burns Centre.

Burns : journal of the International Society for Burn Injuries·2001

Same author

Home inflation of tissue expanders: a safe and reliable alternative.

British journal of plastic surgery·2001

Search research articles

Related Experiment Video

Updated: Mar 11, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Treating hypertrophic scars with silicone gel.

S A Carney¹, C G Cason², J P Gowar³

¹Research biochemist.

Journal of Wound Care

|December 3, 2016

Summary

This preliminary report details a trial using Silastic gel for treating hypertrophic scars. The study investigates the efficacy of this silicone gel in scar management.

More Related Videos

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging

Published on: December 4, 2020

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

Related Experiment Videos

Last Updated: Mar 11, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging

Published on: December 4, 2020

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

Area of Science:

Dermatology
Plastic Surgery
Biomaterials Science

Background:

Hypertrophic scars are a common and often disfiguring consequence of skin injury.
Current treatments for hypertrophic scars have variable efficacy and potential side effects.

Purpose of the Study:

To evaluate the effectiveness of Silastic gel in managing hypertrophic scars.
To assess the safety and tolerability of Silastic gel treatment.

Main Methods:

A preliminary clinical trial was conducted.
Patients with hypertrophic scars were treated with Silastic gel.

Main Results:

The report presents preliminary findings on the outcomes of Silastic gel treatment.
Data on scar improvement and patient response are discussed.

Conclusions:

Silastic gel shows potential as a treatment option for hypertrophic scars.
Further research is warranted to confirm these preliminary findings.