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Related Experiment Video

Updated: Mar 11, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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ERG expression in multiple myeloma-A potential diagnostic pitfall.

Juliana Knief1, Katharina Reddemann1, Jan Gliemroth2

  • 1Department of Pathology, Section of Hematopathology and Endocrine Pathology, University Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.

Pathology, Research and Practice
|December 4, 2016
PubMed
Summary
This summary is machine-generated.

ERG (ETS-related gene) is highly expressed in multiple myeloma, not just prostate cancer. This finding is crucial for accurate diagnosis, preventing misidentification of myeloma as a prostate neoplasm.

Keywords:
ERG expressionMultiple myelomaPlasmacytoma

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Area of Science:

  • Oncology
  • Hematopathology
  • Molecular Diagnostics

Background:

  • ETS-related gene (ERG) expression is a hallmark of prostate cancer, linked to poor prognosis.
  • ERG is also found in certain leukemias and sarcomas but typically absent in other epithelial tumors and lymphomas.

Observation:

  • An index case of spinal metastases initially suspected as prostate cancer, but confirmed as multiple myeloma, showed strong ERG expression.
  • The study investigated ERG expression in 12 multiple myeloma tissue samples.

Findings:

  • All 12 multiple myeloma cases exhibited strong nuclear ERG expression in over 90% of myeloma cells.
  • This contrasts with the typical understanding of ERG expression patterns.

Implications:

  • Strong ERG positivity can be a diagnostic pitfall, potentially leading to misdiagnosis of myeloma as prostate cancer.
  • Pathologists must consider ERG expression in the differential diagnosis of tumors, especially when morphology is ambiguous.
  • Further immunohistochemical analysis is essential for accurate diagnosis in such cases.