From transformation to metastasis: deconstructing the extracellular matrix in breast cancer
Shelly Kaushik1, Michael W Pickup1, Valerie M Weaver2,3,4,5,6,7
1Center for Bioengineering and Tissue Regeneration, Department of Surgery, UCSF, San Francisco, CA, USA.
Abstract:
The extracellular matrix (ECM) is a guiding force that regulates various developmental stages of the breast. In addition to providing structural support for the cells, it mediates epithelial-stromal communication and provides cues for cell survival, proliferation, and differentiation. Perturbations in ECM architecture profoundly influence breast tumor progression and metastasis. Understanding how a dysregulated ECM can facilitate malignant transformation is crucial to designing treatments to effectively target the tumor microenvironment. Here, we address the contribution of ECM mechanics to breast cancer progression, metastasis, and treatment resistance and discuss potential therapeutic strategies targeting the ECM.
Related Concept Videos
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix
The Tumor Microenvironment
Extracellular Matrix
Role of Matrix Metalloproteases in Degradation of ECM
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...


