Dynamic thiol/disulfide homeostasis in children with attention deficit hyperactivity disorder and its relation with
Sibelnur Avcil1, Pınar Uysal2, Mucahit Avcil3
1Adnan Menderes University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Aydın, Turkey.
Background:
The aim of this study was to evaluate a novel oxidative stress marker (thiol/disulfide homeostasis) in attention deficit hyperactivity disorder (ADHD) children for the first time in literature.
Methods:
Ninety children with ADHD diagnosed according to DSM-V and as control group, 65 healthy children were included to the study. Native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol were compared between the groups.
Results:
Total and native thiol levels were significantly higher whereas the disulfide/native thiol ratios were significantly lower in children with ADHD. ADHD combined type appeared to have higher disulfide, disulfide/native thiol and disulfide/total thiol ratios compared to other subtypes. Disulfide levels of the males with ADHD were significantly higher than those of the females with ADHD.
Conclusion:
This study suggests that thiol/disulfide homeostasis is abnormal in children with ADHD. It may be used as a novel OS marker in ADHD children because it is easy, practical, fully automated and relatively inexpensive.
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