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The role of microRNAs in heart failure

Hongjiang Wang1, Jun Cai2

  • 1Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|December 6, 2016
PubMed

Insights

MicroRNAs regulate gene expression and are crucial in cardiovascular diseases like heart failure. This review details their roles in heart failure pathologies, including angiogenesis, hypertrophy, fibrosis, and apoptosis.

Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • Extensive research highlights miRNA involvement in cardiovascular diseases.
  • Heart failure pathogenesis is a significant area of investigation.

Purpose of the Study:

  • To review target genes and functionality of miRNAs in heart failure.
  • To categorize miRNAs based on their target genes' relevance to cardiovascular pathologies.
  • To provide an overview of miRNA roles in cardiovascular health and disease.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Focus on studies investigating miRNA target genes and function in heart failure.
  • Categorization of miRNAs by biological relevance to angiogenesis, cardiac hypertrophy, fibrosis, and apoptosis.

Main Results:

  • Identified specific miRNAs involved in key heart failure processes.
  • Demonstrated miRNA influence on angiogenesis, cardiac hypertrophy, fibrosis, and apoptosis.
  • Highlighted diverse biological signaling pathways regulated by miRNAs in heart failure.

Conclusions:

  • MicroRNAs play significant roles in the pathophysiology of heart failure.
  • Understanding miRNA functionality is key to developing novel therapeutic strategies for cardiovascular diseases.
  • This review consolidates current knowledge on miRNAs in cardiovascular health and disease.
Keywords:
AngiogenesisApoptosisFibrosisHeart failureHypertrophyMicroRNA

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