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Updated: Mar 10, 2026

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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
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A metal-free fluorescence turn-on molecular probe for detection of nucleoside triphosphates
Debabrata Maity1, Mao Li1, Martin Ehlers1
1Institute for Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany. carsten.schmuck@uni-due.de.
Abstract:
We report a fluorescence probe 1, which contains a naphthalimide fluorophore with two symmetric peptidic arms equipped with a tailor-made anion-binding motif, the guanidiniocarbonyl pyrrole moiety, for the detection of nucleoside triphosphates. Upon binding to nucleoside triphosphates, especially ATP, 1 shows significant turn-on fluorescence response. Probe 1 can also be applied for the imaging of ATP in cells.
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