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Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol
Ruth M Barrientos1, Meagan M Kitt2, Heather M D'Angelo2
1Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309-0345, USA ruth.barrientos@colorado.edu.
Abstract:
Here, we present data demonstrating that a 1 d Morris water maze training protocol is effective at producing stable, long-term spatial memory in both young (3 mo old) and aged (24 mo old) F344xBN rats. Four trials in each of four sessions separated by a 2.5 h ISI produced robust selective search for the platform 1 and 4 d after training, in both age groups. A 1 h ISI protocol did not produce good retention. Also, compressing the trials into just two sessions separated by a 2.5 h ISI produced limited retention in only young rats.
