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A Review of Computational Methods for Finding Non-Coding RNA Genes.

Qaisar Abbas1, Syed Mansoor Raza2, Azizuddin Ahmed Biyabani3

  • 1College of Computer and Information Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia. qaabbas@imamu.edu.sa.

Genes
|December 6, 2016
PubMed
Summary

This study reviews computational intelligence (CI) methods for identifying non-coding RNA (ncRNA) genes, addressing challenges in their annotation and classification. It aims to provide a comprehensive framework for future ncRNA gene-finding tool development.

Keywords:
Bayesian networksDNAcomputational intelligencedeep learninggenegenetic algorithmmicro RNAneural networknon-coding RNAsupport vector machine

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Identifying non-coding RNA (ncRNA) genes is a growing bioinformatics challenge.
  • Accurate annotation and classification of ncRNAs require specialized computational intelligence (CI) expertise.
  • Many predicted ncRNA classes lack experimental verification, highlighting the need for robust prediction methods.

Approach:

  • This article provides a detailed summary of CI techniques used for ncRNA gene identification.
  • It differentiates from existing research by offering a broader perspective on CI methodologies.
  • The technical merits of various CI approaches are concisely discussed.

Key Points:

  • CI methods are increasingly applied to predict ncRNA classes.
  • A lack of a unified classification framework hinders the integration of diverse CI approaches.
  • Experimental verification remains a bottleneck for many predicted ncRNAs.

Conclusions:

  • This review consolidates knowledge on CI techniques for ncRNA gene discovery.
  • It identifies limitations in current CI methods for ncRNA gene-finding.
  • The findings aim to guide the development of novel computational tools for ncRNA research.