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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
Comparative immunoexpression of ICAM-1, TGF-β1 and ki-67 in periapical and residual cysts
R Martins1, L Armada, T-C Dos Santos
1Post Graduation Program in Dentistry, Estácio de Sá University, Av. Alfredo Baltazar da Silveira, 580 cobertura, CEP 22790-701, Recreio dos Bandeirantes, Rio de Janeiro/RJ, Brazil, ramoafop@yahoo.com.
Background:
This study compared the immunohistochemical expression of ki-67, transforming growth factor beta 1 (TGF-β1) and intercellular adhesion molecule-1 (ICAM-1) in inflammatory periapical cysts and residual cysts.
Material And Methods:
The study sample was composed by 25 periapical cysts and 25 residual cysts and immunohistochemical reactions were carried out using antibodies directed against ICAM-1, TGF-β1 and ki-67. Clinical, radiological, gross, histological and immunohistochemical data were tabulated for descriptive and comparative analysis using the SPSS software and differences were considered statistically significant when p<0.05%.
Results:
There were no differences between the expression of ICAM-1 (p=0.239) and TGF-β1 (p=0.258) when comparing both groups. Ki-67 labeling index was higher in residual cysts compared to periapical cysts (p=0.017).
Conclusions:
Results from the present study suggest that some specific inflammatory stimuli on residual cysts would modulate their mechanisms of etiopathogenesis, growing and repair.
