Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study
Yinan Zheng1, Marco Sanchez-Guerra2, Zhou Zhang3
1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Health Sciences Integrated PhD Program, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Environmental Research
|December 6, 2016
Summary
Traffic-derived particulate matter (PM) exposure, especially black carbon (BC), is linked to epigenetic changes in histone modifications. These changes may play a role in air pollution-induced chronic diseases.
Area of Science:
- Environmental Epigenetics
- Toxicology
- Occupational Health
Background:
- Airborne particulate matter (PM) is implicated in chronic disease development.
- Histone modifications are key regulators of gene expression via chromatin structure.
- This study investigates traffic-derived PM exposure and its association with global histone H3 modifications.
Purpose of the Study:
- To evaluate the association between traffic-derived PM exposure and four types of global histone H3 modifications.
- To explore potential differences in these associations based on occupation and sex.
Main Methods:
- The Beijing Truck Driver Air Pollution Study involved 120 participants (60 truck drivers, 60 office workers).
- Exposure assessment included ambient PM10, personal PM2.5, and black carbon (BC).
- Global histone modifications (H3K9ac, H3K9me3, H3K27me3, H3K36me3) were measured in blood leukocytes using adjusted linear mixed-effect models.
Main Results:
- Increased 14-day average PM10 exposure was associated with decreased H3K27me3 and H3K36me3 levels.
- Black carbon (BC) exposure showed stronger associations with H3K9ac and H3K36me3 in office workers compared to truck drivers.
- Associations between PM10/BC and histone modifications were stronger in women than in men.
Conclusions:
- Global histone H3 modifications may mediate the effects of traffic-derived PM exposure, particularly BC.
- Further research is needed to understand the role of these modifications in air pollution-related diseases.
- Histone modifications could serve as biomarkers for air pollution-induced disease risk.
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