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Related Concept Videos

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Depletion of Specific Cell Populations by Complement Depletion
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Complement in basic processes of the cell.

Anaïs Jiménez-Reinoso1, Ana V Marin1, José R Regueiro1

  • 1Department of Immunology, Complutense University School of Medicine and Hospital 12 de Octubre Health Research Institute, Madrid, Spain.

Molecular Immunology
|December 7, 2016
PubMed
Summary
This summary is machine-generated.

The complement system is crucial for innate immunity and adaptive responses. Leukocytes utilize complement-derived signals, both external and internal, to regulate immune cell function and responses.

Keywords:
B lymphocyteComplementComplotypeDendritic cellT lymphocyte

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Area of Science:

  • Immunology
  • Innate Immunity
  • Adaptive Immunity

Background:

  • The complement system, a key part of innate immunity, is increasingly recognized for its role in regulating adaptive immune responses.
  • Leukocytes synthesize complement proteins and express complement receptors, influencing their differentiation and effector functions.
  • Cross-talk between complement receptors and other innate receptors, like Toll-like receptors, modulates immune cell behavior.

Purpose of the Study:

  • To review the multifaceted roles of the complement system in immunity.
  • To highlight the autocrine functions of complement proteins synthesized by leukocytes.
  • To explore unconventional roles of complement, including intracellular functions and impact on non-leukocytes.

Main Methods:

  • Review of existing scientific literature and data.
  • Analysis of leukocyte synthesis of complement proteins.
  • Examination of complement receptor expression and function on leukocytes.
  • Investigation of intracellular complement cleavage and its signaling role.

Main Results:

  • Leukocytes synthesize complement proteins and express receptors that regulate their functions.
  • Complement signaling influences T and B lymphocyte and dendritic cell responses.
  • Intracellular complement cleavage generates signals critical for T cell function.
  • Complement proteins have non-leukocyte roles and intracellular functions.

Conclusions:

  • Leukocytes are highly sensitive to extracellular and intracellular complement-derived information.
  • The complement system offers significant therapeutic intervention potential.
  • New hypotheses regarding conserved major histocompatibility complex complotypes can be generated.