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Related Experiment Video

Updated: Mar 10, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Quantitative visual tests after poorly recovered optic neuritis due to multiple sclerosis.

Erin E Longbrake1, Samantha Lancia1, Nhial Tutlam1

  • 1Department of Neurology, Washington University in St. Louis, St Louis, MO, United States.

Multiple Sclerosis and Related Disorders
|December 7, 2016
PubMed
Summary

The Pelli Robson (PR) contrast sensitivity chart is effective for assessing visual impairment in multiple sclerosis (MS) patients. Visual quality of life is linked to retinal nerve fiber layer thinning.

Keywords:
Multiple sclerosisVisual acuity

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Clinical Vision Science

Background:

  • Visual dysfunction is common in multiple sclerosis (MS) but many vision tests lack formal evaluation in MS patients.
  • Standardized assessment of visual function is crucial for managing MS-related visual impairment.

Purpose of the Study:

  • To evaluate various visual acuity and contrast sensitivity tests in MS patients with moderate to severe visual dysfunction.
  • To assess central/peripheral vision, retinal structure, electrophysiologic function, and quality of life.

Main Methods:

  • Cross-sectional study of 46 MS patients with stable optic neuritis.
  • Utilized Snellen charts, Sloan low contrast charts, Pelli Robson (PR) charts, optical coherence tomography (OCT), visual fields, Farnsworth Munsell 100-hue test, visual evoked potentials (VEP), and VFQ-25.

Main Results:

  • Pelli Robson (PR) chart identified contrast sensitivity in 98% of eyes; 2.5% contrast chart identified it in 43%.
  • Low contrast tests correlated with retinal nerve fiber layer (RNFL) thickness, visual fields, and color vision, but not VEPs.
  • Reduced RNFL thickness (<75µm) correlated with a significant drop in visual function quality of life (VFQ-25) scores.

Conclusions:

  • The Pelli Robson (PR) contrast sensitivity chart is a suitable single measure for MS-related visual impairment.
  • Visual quality of life in MS patients is significantly associated with RNFL thinning below 75µm.