Related Experiment Video
Updated: Mar 10, 2026
10:07
Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
Published on: March 20, 2012
27.2K
Teratogenic Effect of Radotinib: Case Report.
Juyoung Cheon1, Jung Whan Ahn1, Kyung Min Park1
1Department of Obstetrics and Gynecology, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Anticancer Research
|December 7, 2016
Summary
Newly developed tyrosine kinase inhibitors (TKIs) like radotinib may pose risks during pregnancy. This case highlights potential fetal structural abnormalities, emphasizing the need for contraception counseling in women of childbearing age.
Area of Science:
- Hematology
- Oncology
- Teratology
Background:
- Simultaneous pregnancy and chronic myeloid leukemia (CML) is uncommon.
- Use of tyrosine kinase inhibitors (TKIs) during pregnancy is rare, especially with newer agents.
- Limited data exists on the fetal effects of novel TKIs.
Observation:
- A 22-year-old woman with CML conceived while on radotinib, a novel TKI.
- The first pregnancy was terminated due to concerns about radotinib's teratogenic potential.
- The second pregnancy resulted in a full-term delivery with an infant exhibiting facial deformity and congenital laryngomalacia.
Findings:
- Structural abnormalities were observed in an infant exposed to radotinib during the first trimester.
- Radotinib use in early pregnancy was associated with fetal malformations.
Implications:
- Thorough counseling on contraception is crucial for women of childbearing age prescribed radotinib.
- Further research is needed to understand the safety profile of novel TKIs in pregnancy.
- This case underscores the potential teratogenic risks of certain CML treatments during gestation.
Related Concept Videos
01:07Teratogenicity
4.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
01:24Drug Toxicity: Risk factors
88
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
88