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Platelet count and platelet indices in women with preeclampsia
Muneera A AlSheeha1, Rafi S Alaboudi1, Mohammad A Alghasham1
1Department of Obstetrics and Gynaecology, College of Medicine, Qassim University, Buriadah.
Insights
Platelet count (PC) below 248.0×10³ /µL and a PC to mean platelet volume (MPV) ratio of 31.2 can predict preeclampsia. These platelet indices offer valuable insights for early detection of this pregnancy complication.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Reproductive Medicine
Background:
- Preeclampsia pathophysiology remains incompletely understood.
- Platelet indices show potential utility in predicting preeclampsia.
- Early detection of preeclampsia is crucial for maternal and fetal health.
Purpose of the Study:
- To compare platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia versus healthy controls.
- To evaluate the diagnostic value of these platelet indices for preeclampsia.
Main Methods:
- A case-control study was conducted at Qassim Hospital, Kingdom of Saudi Arabia.
- Sixty preeclamptic women (cases) and sixty healthy pregnant women (controls) were included.
- Platelet count, MPV, PDW, and PC to MPV ratio were analyzed.
Main Results:
- No significant differences in age, parity, or BMI between groups.
- Platelet count (PC) and PC to MPV ratio were significantly lower in preeclamptic women.
- PDW and MPV did not differ significantly between groups.
- Receiver operating characteristic (ROC) curve analysis identified a PC cutoff of 248.0×10³ /µL and a PC to MPV ratio cutoff of 31.2 for preeclampsia prediction.
Conclusions:
- Low platelet count (PC <248.0×10³ /µL) is a significant predictor of preeclampsia.
- A PC to MPV ratio of 31.2 is also a valid predictor of preeclampsia.
- These platelet indices can aid in the diagnosis and risk assessment of preeclampsia.
Background:
Although the exact pathophysiology of preeclampsia is not completely understood, the utility of different platelets indices can be utilized to predict preeclampsia.
Objective:
To compare platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and PC to MPV ratio in women with preeclampsia compared with healthy controls.
Setting:
Qassim Hospital, Kingdom of Saudi Arabia.
Design:
A case-control study. Sixty preeclamptic women were the cases and an equal number of healthy pregnant women were the controls.
Results:
There was no significant difference in age, parity, and body mass index between the study groups. Sixteen and 44 of the cases were severe and mild preeclampsia, respectively. There was no significant difference in PDW and MPV between the preeclamptic and control women. Both PC and PC to MPV ratios were significantly lower in the women with preeclampsia compared with the controls. There was no significant difference in the PC, PDW, MPV, and PC to MPV ratio when women with mild and severe preeclampsia were compared. Using receiver operating characteristic (ROC) curves, the PC cutoff was 248.0×103/µL for diagnosis of pre-eclampsia (P=0.019; the area under the ROC curve was 62.4%). Binary regression suggests that women with PC <248.010×103/µL were at higher risk of preeclampsia (odds ratio =2.2, 95% confidence interval =1.08-4.6, P=0.03). The PC/MPV cutoff was 31.2 for diagnosis of preeclampsia (P=0.035, the area under the ROC curve was 62.2%).
Conclusion:
PC <248.010×103/µL and PC to MPV ratio 31.2 are valid predictors of preeclampsia.
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