Related Experiment Video

Updated: Mar 10, 2026

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

9.6K

Changing epidemiology of non-cystic fibrosis bronchiectasis

Semiha Bahçeci1, Sait Karaman1, Hikmet Tekin Nacaroğlu1

  • 1Department of Pediatrics, Dr. Behçet Uz Pediatric Hospital, İzmir, Turkey.

The Turkish Journal of Pediatrics
|December 7, 2016
PubMed

Insights

Non-cystic fibrosis bronchiectasis etiology is shifting, with increases in primary ciliary dyskinesia and immune deficiencies. This condition can be managed long-term with medical treatment.

Area of Science:

  • Pediatrics
  • Pulmonology
  • Medical Research

Background:

  • Non-cystic fibrosis bronchiectasis presents a growing health concern, linked to antibiotic misuse and rising cases of protracted bacterial bronchitis.
  • Understanding the evolving causes of bronchiectasis is crucial for effective management.

Purpose of the Study:

  • To investigate the changes in the etiological landscape of bronchiectasis over a ten-year period.
  • To identify trends in the causes of pediatric bronchiectasis.

Main Methods:

  • Retrospective analysis of 110 pediatric patients admitted to Behçet Uz Children Hospital between 2005 and 2015.
  • Etiological factors were identified for each case.

Main Results:

  • Primary ciliary dyskinesia (26.4%) and protracted bacterial bronchitis (22.8%) were the leading causes.
  • Over the study period, asthma and tuberculosis etiologies decreased, while primary ciliary dyskinesia and primary immune deficiency etiologies increased.
  • In 15.4% of cases, the etiology remained unclear. 91% of patients received medical treatment.

Conclusions:

  • The etiology of non-cystic fibrosis bronchiectasis shows a dynamic shift, with increasing prevalence of genetic and immune-related conditions.
  • Non-cystic fibrosis bronchiectasis is manageable with long-term medical treatment strategies.

Keywords:
changing epidemiologychildrennon-cystic fibrosis bronchiectasis

More Related Videos

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

24.0K
Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression08:58

Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression

Published on: April 18, 2025

1.1K

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
982
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
597
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.3K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.0K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.1K