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Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

13.6K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.6K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

690
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension I: Introduction01:28

Hypertension I: Introduction

1.1K
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Longitudinal Studies01:26

Longitudinal Studies

595
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

302
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Related Experiment Video

Updated: Mar 10, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

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Longitudinal Association between Selenium Levels and Hypertension in a Rural Elderly Chinese Cohort.

L Su1, Y Jin, F W Unverzagt

  • 1Dr. Sujuan Gao, Department of Biostatistics, Indiana University School of Medicine, 410 West 10th Street, #3000, Indianapolis, IN 46202-2872, Phone: U.S. (317) 274-0820 Fax: (317)274-2678,

The Journal of Nutrition, Health & Aging
|December 8, 2016
PubMed
Summary

High selenium levels were associated with increased risk of developing hypertension in elderly Chinese individuals. This study suggests a potential harmful role of elevated selenium in hypertension development among this population.

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Last Updated: Mar 10, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

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Area of Science:

  • Nutritional Epidemiology
  • Cardiovascular Health
  • Gerontology

Background:

  • Inconsistent previous findings on selenium and hypertension association.
  • Limited research on selenium's role in hypertension among the elderly.
  • Need to investigate selenium's impact on cardiovascular health in aging populations.

Purpose of the Study:

  • To investigate the relationship between selenium levels and hypertension in rural elderly Chinese.
  • To examine associations with both prevalent and incident hypertension.
  • To assess selenium's role in the development of high blood pressure in older adults.

Main Methods:

  • Longitudinal study design in a community-based setting in rural China.
  • Inclusion of 2000 elderly participants (aged 65+).
  • Nail selenium levels measured at baseline; blood pressure and hypertension history tracked over 7 years using logistic and Cox regression models.

Main Results:

  • Baseline hypertension rate was 63.50% with a mean nail selenium level of 0.413±0.183μg/g.
  • Higher selenium levels correlated with higher blood pressure and increased hypertension rates.
  • Elevated selenium levels (quintiles 2-5) showed significantly increased hazard ratios for incident hypertension compared to the lowest quintile.

Conclusions:

  • Findings suggest high selenium intake may contribute to hypertension development in the elderly.
  • Further research is warranted to confirm these results.
  • Elucidation of the biological mechanisms underlying selenium's role in hypertension is needed.