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Immune responses to bioengineered organs.

Jordi Ochando1, Dominique Charron, Pedro M Baptista

  • 1aDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA bHLA&MEDECINE 'Jean Dausset' Laboratory Network and Transplantex, Hôpital Saint-Louis, Inserm U 976 Université Paris-Diderot, Paris, France cJiao Tong University, Shanghai, China dInstituto de Investigacion Sanitaria de Aragon (IIS Aragon) eCIBERehd, Zaragoza, Spain fDepartment of Surgery, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, The Shriners Hospitals for Children, Boston, Massachusetts, USA.

Current Opinion in Organ Transplantation
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PubMed
Summary
This summary is machine-generated.

Bioengineered organs offer a promising solution to the organ transplant shortage. However, potential immune responses to progenitor cells and non-self scaffolds require further investigation for safe clinical application.

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Area of Science:

  • Regenerative Medicine
  • Transplant Immunology
  • Tissue Engineering

Background:

  • Organ transplantation faces a critical shortage, with demand for organs significantly outpacing availability.
  • In 2015, 9,079 deceased organ donors facilitated 29,851 transplants in the US, highlighting the persistent gap.
  • The increasing number of patients needing transplants annually exacerbates this fundamental problem.

Purpose of the Study:

  • To explore the potential of bioengineered organs as an unlimited source for transplantation.
  • To review the host immune response to progenitor cells used in bioengineering.
  • To discuss the implications of using non-self biological scaffolds in organ bioengineering.

Main Methods:

  • Utilizing complex three-dimensional scaffolds to support cellular activity and tissue remodeling.
  • Employing tissue recellularization protocols with progenitor cells.
  • Integrating knowledge from transplant immunology, tissue engineering, and stem cell biology.

Main Results:

  • Bioengineered organs hold promise for increasing the organ supply for transplantation.
  • The technology involves scaffold-based tissue engineering and progenitor cell recellularization.
  • This approach integrates multiple scientific disciplines to create potential donor organs.

Conclusions:

  • Bioengineered organs are theorized to evade immune rejection, but this requires detailed study.
  • The host immune response to various progenitor cells needs thorough investigation.
  • The immunological implications of using non-self biological scaffolds in bioengineered organs warrant further examination.