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Memantine, used for Alzheimer's disease, can cause movement disorders like chorea and dystonia if the dose is accidentally doubled. This highlights risks when switching between immediate-release and extended-release formulations.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Neurology

Background:

  • Memantine is an NMDA receptor antagonist used to treat Alzheimer's disease.
  • It may also influence dopaminergic pathways at higher concentrations.
  • Switching between immediate-release (IR) and extended-release (XR) formulations requires careful consideration.

Observation:

  • A patient with Alzheimer's disease inadvertently doubled her memantine XR dose.
  • This occurred due to a misunderstanding when switching from memantine IR to XR.
  • The patient developed chorea and dystonia following the dose escalation.

Findings:

  • Accidental memantine XR overdose led to the development of movement disorders.
  • The patient's symptoms included chorea and dystonia.
  • This adverse event was linked to the medication switch and dose increase.

Implications:

  • Clinicians must be vigilant about potential adverse events when transitioning patients between memantine IR and XR.
  • Patient and caregiver education is crucial to prevent medication errors.
  • This case underscores the importance of precise dosing and administration instructions for memantine XR.