Bioactive mesoporous wollastonite particles for bone tissue engineering

The current investigation was aimed at identifying the role of mesoporous wollastonite particles on the healing of rat tibial bone defect. The bone defect was created with a 3-mm-diameter dental drill, and it was filled with mesoporous wollastonite particles. After second and fourth weeks of filling treatments, it was found that mesoporous wollastonite particles promoted bone formation as evidenced by X-ray, histological, scanning electron microscope, and energy-dispersive spectra studies. X-ray study showed the closure of drill hole as seen by high-dense radio-opacity image. Histological analysis depicted the deposition of collagen in the bone defect area in response to mesoporous wollastonite particles' treatment. Scanning electron microscope-energy-dispersive spectra analyses of the sectioned implants also identified the deposition of apatite by these particles. Thus, our results suggested that mesoporous wollastonite particles have bioactive properties, and they can be used as a suitable filling material for promotion of bone formation in vivo.