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Developments in multiple breath washout testing in children with cystic fibrosis

Clare Saunders1,2, Katie Bayfield1,2, Samantha Irving1,2

  • 1a NHLI, Imperial College London , UK.

Current Medical Research and Opinion
|December 10, 2016
PubMed

Insights

Lung clearance index (LCI) is an emerging, non-invasive tool for monitoring pediatric cystic fibrosis (CF). Standardization efforts aim to increase its clinical use beyond research settings.

Area of Science:

  • Pulmonary Medicine
  • Pediatric Respiratory Health

Background:

  • Lung clearance index (LCI) is gaining recognition for monitoring pediatric cystic fibrosis (CF).
  • This non-invasive technique is reproducible and suitable for all ages, increasingly used in clinical trials.
  • Current application is primarily as a research tool, with growing interest in clinical integration.

Purpose of the Study:

  • To review the background and utility of LCI in pediatric CF.
  • To discuss technical considerations and limitations of LCI measurements.
  • To provide examples of LCI application in clinical and research settings.

Main Methods:

  • Review of existing literature and ongoing collaborative efforts.
  • Analysis of technical aspects influencing LCI measurement quality.
  • Case examples illustrating LCI's role in CF management and research.

Main Results:

  • LCI is a valuable, non-invasive monitoring tool for pediatric CF.
  • Operator skill and a calm testing environment are crucial for accurate LCI results.
  • Standardization is key to broader clinical adoption.

Conclusions:

  • LCI is an important addition to pediatric CF monitoring.
  • Standardization is an ongoing multicenter effort.
  • Further integration into clinical practice is anticipated.
Abstract

Keywords:
Childcystic fibrosislung clearance indexmultiple breath washoutspirometry

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