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Related Experiment Video

Updated: Mar 10, 2026

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
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The "White Gray Sign" Identifies the Central Sulcus on 3T High-Resolution T1-Weighted Images.

O F Kaneko1, N J Fischbein1, J Rosenberg1

  • 1From the Department of Radiology, Neuroradiology Section, Stanford University, Stanford, California.

AJNR. American Journal of Neuroradiology
|December 10, 2016
PubMed
Summary

The "white gray sign," a reduced gray-white matter contrast, reliably identifies the central sulcus on 3D inversion recovery fast-spoiled gradient-echo images. This new sign offers improved accuracy over traditional methods for this key brain landmark.

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Area of Science:

  • Neuroimaging
  • Radiology
  • Anatomy

Background:

  • The central sulcus is a critical anatomical landmark in the brain.
  • Current methods for identifying the central sulcus rely on variable gyral and sulcal patterns, limiting accuracy.

Purpose of the Study:

  • To describe and assess the accuracy of a novel sign, the "white gray sign," characterized by reduced gray-white matter contrast along the central sulcus.
  • To evaluate the reliability of this sign in identifying the central sulcus on specific MRI sequences.

Main Methods:

  • Retrospective review of 51 functional MRIs (fMRIs) with T1-weighted 3D inversion recovery fast-spoiled gradient-echo sequences.
  • Quantitative analysis of gray-white contrast in 25 normal hemispheres.
  • Evaluation of the "white gray sign" and other established signs by two raters on 51 fMRIs.

Main Results:

  • Significantly reduced gray-white contrast was observed along the central sulcus compared to adjacent sulci (P < .001).
  • The "white gray sign" was correctly identified by both raters in all hemispheres.
  • The "white gray sign" demonstrated the highest inter-rater agreement and was most frequently present.

Conclusions:

  • Reduced gray-white contrast, or the "white gray sign," is a reliable indicator for central sulcus identification.
  • This sign is particularly useful on 3D inversion recovery fast-spoiled gradient-echo images.
  • The "white gray sign" offers an accurate and reproducible method for locating the central sulcus.