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Terminal H-reflex Measurements in Mice

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Published on: June 16, 2022

Exposure to Ketamine Anesthesia Affects Rat Impulsive Behavior.

António Melo¹, Hugo Leite-Almeida¹, Clara Ferreira¹

¹Life and Health Sciences Research Institute (ICVS), School of Medicine, University of MinhoBraga, Portugal; ICVS/3B's - PT Government Associate LaboratoryBraga/Guimarães, Portugal.

Frontiers in Behavioral Neuroscience

|December 10, 2016

Summary

Repeated ketamine anesthesia disrupts inhibitory control, increasing impulsive behavior in animals. This effect is linked to changes in brain cell structure, suggesting ketamine may modulate impulsivity.

Keywords:

impulsive behavior ketamine ketamine anesthesia nucleus accumbens rat model striatum

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Area of Science:

Neuroscience
Anesthesiology
Behavioral Science

Background:

Ketamine is a general anesthetic known for acute effects like loss of responsiveness.
Concerns exist regarding potential long-term behavioral changes from repeated ketamine exposure.
Existing research primarily focuses on cognitive and memory effects of general anesthesia.

Purpose of the Study:

To investigate if repeated ketamine general anesthesia disrupts motivational behavior, specifically impulsivity.
To assess the impact of ketamine exposure on impulsive behavior traits.

Main Methods:

Animals were tested using the variable delay-to-signal (VDS) paradigm to measure impulsive behavior.
Morphological changes in accumbal and striatal medium spiny neurons were examined post-ketamine exposure.

Main Results:

Ketamine-exposed animals exhibited altered inhibitory control, showing increased premature actions during longer delays.
A failure to modulate premature actions across delay periods was observed in ketamine-exposed animals compared to controls.
Increased dendritic length of nucleus accumbens medium spiny neurons paralleled the observed behavioral changes.

Conclusions:

Ketamine anesthesia acutely affects impulsive behavior.
Repeated ketamine exposure can lead to lasting disruptions in inhibitory control.
Ketamine shows potential as a modulator of impulsivity traits.