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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Resources for Systems Genetics.

Robert W Williams1, Evan G Williams2

  • 1Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, 77 S. Manassas Street, Memphis, TN, 38163, USA. rwilliams@uthsc.edu.

Methods in Molecular Biology (Clifton, N.J.)
|December 10, 2016
PubMed
Summary
This summary is machine-generated.

Systems genetics utilizes diverse populations, from admixed to simple crosses, to study genetic complexity. This guide aids researchers in selecting appropriate genetic resources based on specific research questions, costs, and breeding ease.

Keywords:
Collaborative Cross (CC)Congenic linesConsomic and chromosome substitution linesDiversity outcross (DO)Gene-by-environment interactions (G × E)Genetic reference population (GRP)Heterogeneous stock (HS)Hybrid diversity panel (HDP)RI intercross (RIX) and RI backcross (RIB) progenyRecombinant congenic strainsRecombinant inbred (RI)Reduced complexity cross (RCC)

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Area of Science:

  • Genetics
  • Systems Biology
  • Bioinformatics

Background:

  • Systems genetics leverages diverse populations with varying genetic complexity.
  • Resources range from highly admixed populations (Collaborative Cross, Diversity Outcross) to simpler crosses (consomic strains).

Purpose of the Study:

  • To guide investigators in selecting optimal genetic resources for systems genetics studies.
  • To inform decisions based on specific research questions and resource characteristics.

Main Methods:

  • Evaluation of factors including cost, availability, and breeding ease for different genetic resources.
  • Consideration of common research scenarios and their associated resource requirements.

Main Results:

  • Recommendations for complementary resource utilization.
  • Guidance on minimizing the depth of genome or strain resampling.

Conclusions:

  • Informed selection of genetic resources enhances systems genetics research efficiency.
  • Strategic use of diverse populations and complementary resources is key for robust genetic studies.