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Related Concept Videos

Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Human Genetics01:28

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Genetic Variation01:25

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Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
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Incomplete Dominance01:43

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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GeneNetwork: A Toolbox for Systems Genetics.

Megan K Mulligan1, Khyobeni Mozhui2, Pjotr Prins3,2

  • 1Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, 855 Monroe Ave., Suite 515, Memphis, TN, 38163, USA. mkmulligan@uthsc.edu.

Methods in Molecular Biology (Clifton, N.J.)
|December 10, 2016
PubMed
Summary
This summary is machine-generated.

Systems genetics explores genetic impacts on all biological levels. This protocol details using the GeneNetwork web service for analyzing complex genetic data and understanding gene variants linked to addiction and aging.

Keywords:
Allen Brain AtlasBioGPSGEOGTExGWAS CatalogGemmaGeneRIFGeneWeaverInterval mappingManhattan plotMetabolomicsMetagenomicsNCBIPLINKPair scanPrincipal component analysisProteomicsR/qtlRecombinant inbred strainReverse geneticsTest crossUCSC Genome BrowserWGCNAWebGestaltWebQTLdbSNPeQTL analysis

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Area of Science:

  • Genetics
  • Systems Biology
  • Bioinformatics

Background:

  • Systems genetics integrates diverse data types (mRNAs, proteins, metabolites, traits) to understand genetic variation's impact.
  • Analyzing complex biological systems necessitates advanced statistical tools to identify covariation and causal relationships.
  • GeneNetwork is a free, web-based resource facilitating systems genetics research.

Purpose of the Study:

  • To provide a protocol for utilizing the GeneNetwork web service for systems genetics research.
  • To demonstrate workflows for navigating and analyzing massive multiscalar datasets.
  • To illustrate the application of systems genetics tools in human and mouse models.

Main Methods:

  • Utilizing the GeneNetwork web service and its extensive toolkit for data analysis and synthesis.
  • Developing and explaining workflows for accessing and integrating diverse biological data.
  • Applying statistical methods to identify patterns of covariation and causal links.

Main Results:

  • Demonstrated effective navigation of massive multiscalar datasets within GeneNetwork.
  • Provided practical workflows for systems genetics analysis and synthesis.
  • Successfully evaluated gene variant linkage to addiction and aging using human and mouse cohorts.

Conclusions:

  • The GeneNetwork web service is a powerful, accessible resource for systems genetics.
  • This protocol enables researchers to conduct comprehensive analyses of genetic variation and its effects.
  • Systems genetics approaches, exemplified by these case studies, are crucial for understanding complex traits like addiction and aging.