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Updated: Mar 10, 2026

Sequencing of mRNA from Whole Blood using Nanopore Sequencing
Published on: June 3, 2019
Nanopores and Nanochannels: From Gene Sequencing to Genome Mapping
Stefan Howorka1, Zuzanna Siwy2
1Department of Chemistry, Institute of Structural Molecular Biology, University College London , London WC1H 0AJ, United Kingdom.
Abstract:
DNA strands can be analyzed at the single-molecule level by isolating them inside nanoscale holes. The strategy is used for the label-free and portable sequencing with nanopores. Nanochannels can also be applied to map genomes with high resolution, as shown by Jeffet et al. in this issue of ACS Nano. Here, we compare the two strategies in terms of biophysical similarities and differences and describe that both are complementary and can improve the DNA analysis for genomic research and diagnostics.
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