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A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors

Kevin B Teuscher1,2, Min Zhang1, Haitao Ji1,3,2

  • 1Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute , 12902 Magnolia Drive, Tampa, Florida 33612-9416, United States.

Journal of Medicinal Chemistry
|December 10, 2016
PubMed
Summary

A new HPLC-MS protocol accurately measures small-molecule inhibitor bioavailability in cells. This method characterizes intracellular concentrations, stability, and binding, aiding drug development for cancer cells.

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