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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
Published on: December 27, 2017
Thrombocytopenia and infections.
Massimo Franchini1, Dino Veneri2, Giuseppe Lippi3
1a Department of Hematology and Transfusion Medicine , Carlo Poma Hospital , Mantova , Italy.
Infectious diseases like hepatitis C virus (HCV), human immunodeficiency virus (HIV), and Helicobacter pylori can cause acquired thrombocytopenia. Treating these infections may improve platelet counts.
Area of Science:
- Infectious Diseases
- Hematology
- Immunology
Background:
- Acquired thrombocytopenia has diverse causes, with infections being a significant factor.
- Low platelet counts are frequently observed alongside other laboratory abnormalities in infectious diseases.
Purpose of the Study:
- To review the pathogenic mechanisms of thrombocytopenia in infections.
- To focus on prevalent infections linked to thrombocytopenia: hepatitis C virus (HCV), human immunodeficiency virus (HIV), and Helicobacter pylori.
Main Methods:
- This is a narrative review.
- The review covers pathogenic mechanisms and clinical associations of specific infections with thrombocytopenia.
Main Results:
- HCV and HIV infections are common causes of acquired thrombocytopenia in at-risk individuals.
- Helicobacter pylori infection can lead to secondary immune thrombocytopenia.
Conclusions:
- Suspect HCV or HIV in patients with isolated thrombocytopenia and risk factors.
- Eradicating Helicobacter pylori can increase platelet counts in affected patients, potentially avoiding aggressive treatments.
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