A Randomized Controlled Trial of End-Tidal Carbon Dioxide Detection of Preterm Infants in the Delivery Room

To compare the ability of qualitative versus quantitative methods of end-tidal carbon dioxide (EtCO₂) detection to maintain normocarbia during face mask ventilation (FMV) of preterm infants (<32 weeks) in the delivery room.

Preterm infants <32 weeks were randomly assigned to the use of a disposable PediCap EtCO₂ detector (Covidien, Dublin, Ireland) (qualitative) or a Microstream side stream capnography device (Covidien) (quantitative) for FMV in the delivery room, via a NeoPuff T-piece resuscitator (Fisher and Paykel, Auckland, New Zealand). The primary outcome was the presence of normocarbia, based on partial pressure of CO₂ (PaCO₂) readings obtained in the neonatal intensive care unit within an hour of birth. Normocarbia was defined as a PaCO₂ measure between 37.5 and 60 mm Hg (5-8 kPa).

Of the 59 infants included, 59% (35/59) were within the PaCO₂ target range within an hour of birth. There was no difference in the primary outcome; 64% (21/33) of infants in the quantitative group were within the PaCO₂ range compared with 54% (14/26) in the qualitative group (P = .594); and 93% of participants <28 weeks' gestation were within the PaCO₂ normocarbic range (90% [9/10] in quantitative group and 100% [5/5] in the qualitative group [P = 1]). There was no difference in the intubation rate, days of ventilation, or bronchopulmonary dysplasia rates between the 2 groups.

Quantitative or qualitative EtCO₂ detection methods are both feasible for FMV in the delivery room. Although there was no difference in the incidence of normocarbia, the use of either form of EtCO₂ monitoring should be considered during newborn stabilization, especially in infants less than 28 weeks' gestation.

ISRCTN: ISRCTN10934870.