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Sedentary time assessed by actigraphy and mortality: The Rotterdam Study
Chantal M Koolhaas1, Klodian Dhana2, Frank J A van Rooij1
1Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
Sedentary behavior, measured by actigraphy, is linked to increased mortality risk. This association may be influenced by other activity measures, warranting further investigation into distinct effects.
Area of Science:
- Epidemiology
- Gerontology
- Public Health
Background:
- Sedentary behavior is a potential mortality risk factor.
- Questionnaire-based studies are limited by reporting errors.
- Objective measurement of sedentary time is needed.
Purpose of the Study:
- To examine the association between actigraphy-assessed sedentary time and mortality.
- To determine if sedentary behavior's mortality risk is independent of physical activity and daily living activities.
Main Methods:
- Prospective cohort study (Rotterdam Study) with 1839 participants (aged 45-98).
- Actigraphy used for objective sedentary time measurement over seven days.
- Cox proportional hazard models analyzed mortality risk over 11 years.
Main Results:
- Each additional hour/day of sedentary time showed a trend towards increased mortality (HR: 1.09).
- Participants with ≥11h/day sedentary time had higher mortality risk (HR: 1.80) compared to <8h/day.
- Associations were attenuated after adjusting for physical activity and activities of daily living.
Conclusions:
- Sedentary behavior, objectively measured, appears to be a risk factor for mortality.
- The independent contribution of sedentary behavior to mortality risk requires further study.
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