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Diplopia and Sjogren's disease: A rare case report
Kaushalendra Tripathi1, Richa Tripathi2, Navid Seraji-Bozorgzad3
1SMT. NHL Medical Municipal College, Gujarat, India.
Journal of Neuroimmunology
|December 13, 2016
Summary
Sjogren's syndrome can affect cranial nerves, including the oculomotor and abducens nerves, leading to ophthalmoplegic symptoms. Early diagnosis and treatment with steroids can resolve these rare neurological manifestations.
Area of Science:
- Neurology
- Immunology
- Ophthalmology
Background:
- Sjogren's syndrome is a chronic autoimmune disease targeting exocrine glands.
- Neurological involvement, particularly cranial nerve lesions, is a rare complication.
- Trigeminal nerve involvement is the most commonly reported neurological manifestation.
Observation:
- A middle-aged woman presented with ophthalmoplegic symptoms suggestive of cranial nerve dysfunction.
- Clinical examination revealed involvement of the oculomotor (third) and abducens (sixth) nerves.
- Symptoms resolved effectively following steroid therapy.
Findings:
- Serum analysis confirmed the presence of anti-SSA antibodies, a common marker for Sjogren's syndrome.
- Neuroimaging demonstrated enhancement of the affected cranial nerves.
- Literature review indicated a higher prevalence of third and sixth nerve involvement in Sjogren's syndrome than previously recognized.
Implications:
- This case highlights the importance of considering Sjogren's syndrome in patients with unexplained ophthalmoplegia.
- Advanced imaging techniques facilitate the identification of cranial nerve involvement in autoimmune disorders.
- Increased recognition of these neurological manifestations may improve diagnostic accuracy and patient management in Sjogren's syndrome.
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