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Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
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Lung Mass in Smokers.

George R Washko1, Gregory L Kinney2, James C Ross3

  • 1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115.

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|December 13, 2016
PubMed
Summary
This summary is machine-generated.

Increased lung mass in smokers is linked to worse lung function decline. This study found higher lung mass in early COPD, predicting future FEV1 decline in smokers.

Keywords:
COPDCT scanLung massemphysemasmoking

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Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Epidemiology

Background:

  • Emphysema involves airspace dilation and interstitial changes.
  • Smokers may exhibit increased lung mass due to inflammation and remodeling.
  • Understanding lung mass associations in smokers is crucial for COPD research.

Purpose of the Study:

  • To investigate the epidemiologic and clinical associations of lung mass (LM) in smokers.
  • To determine if baseline LM predicts lung function decline over time.

Main Methods:

  • Analysis of baseline computed tomography (CT) and clinical data from 8156 smokers in the COPDGene Study.
  • Lung mass (LM) calculated from CT scans.
  • Regression analysis to assess LM association with FEV1 and FEV1 decline over 5 years in 1623 subjects.

Main Results:

  • Smokers with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 COPD had significantly greater LM than healthy smokers or those with GOLD 2-4 COPD.
  • Baseline LM was a significant predictor of the rate of FEV1 decline (decline per 100g: -4.7 ± 1.7 mL/y).

Conclusions:

  • Smokers exhibit a biphasic radiological remodeling process, necessitating consideration in longitudinal CT studies.
  • Baseline lung mass is a predictive marker for future lung function decline in smokers.