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Alamethicin for using in bioavailability studies? - Re-evaluation of its effect.

Maren Vollmer1, Mirko Klingebiel1, Sascha Rohn1

  • 1Institute of Food Chemistry, Hamburg School of Food Science, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|December 13, 2016
PubMed
Summary

Alameticin concentration significantly impacts drug metabolism assays. Optimizing its levels enhances glucuronidation activity in hepatic microsomes, crucial for predicting drug elimination in vivo.

Keywords:
AlamethicinIn vitro glucuronidationLog P valueMetabolismPhenolic compounds

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