68Ga-PSMA PET/CT Imaging in Multiple Myeloma

Area of Science:

• Nuclear Medicine
• Oncology
• Radiopharmaceuticals

Background:

• Gallium-labeled prostate-specific membrane antigen (Ga-PSMA) PET/CT is established for prostate cancer imaging.
• Emerging evidence suggests Ga-PSMA PET/CT utility in non-prostate malignancies, potentially linked to tumor neoangiogenesis.

Observation:

• This report details the successful application of Ga-PSMA PET/CT in visualizing multiple myeloma.
• Multiple myeloma lesions demonstrated intense Ga-PSMA avidity.

Findings:

• Ga-PSMA PET/CT effectively images multiple myeloma lesions.
• The observed high avidity indicates PSMA expression in multiple myeloma.

Implications:

• Ga-PSMA PET/CT expands its diagnostic role beyond prostate cancer to include hematologic malignancies like multiple myeloma.
• The intense PSMA avidity in multiple myeloma lesions opens avenues for targeted radionuclide therapy, specifically with Lutetium-PSMA (Lu-PSMA) theranostics.