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Updated: Mar 10, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
HPV-associated oropharyngeal squamous cell carcinoma
Timothy J Smith1, Anthony Mendez, Carrlene Donald
1Timothy J. Smith recently completed a PA fellowship in otolaryngology at the Mayo Clinic in Phoenix, Ariz. Anthony Mendez is an instructor in the Department of Otolaryngology and Head/Neck Surgery at the Mayo Clinic College of Medicine in Phoenix and director of the PA fellowship in otolaryngology. Carrlene Donald practices in the Department of Otolaryngology and Head/Neck Surgery at the Mayo Clinic. Thomas Harold Nagel is an assistant professor in the Department of Otolaryngology and Head/Neck Surgery at the Mayo Clinic. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Abstract:
Human papillomavirus (HPV) can infect the tonsillar tissues of the oropharynx and is associated with oropharyngeal squamous cell carcinoma. This article provides an overview to guide primary care providers in screening patients for oropharyngeal cancer and making appropriate referrals. The article also reviews available HPV vaccines and immunization adherence rates.
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