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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Non-Canonical Cell Death Induced by p53

Atul Ranjan1, Tomoo Iwakuma2

  • 1Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA. aranjan@kumc.edu.

International Journal of Molecular Sciences
|December 13, 2016
PubMed

Insights

The tumor suppressor p53 regulates various programmed cell death pathways beyond apoptosis. This review explores p53

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • Programmed cell death is crucial for multicellular organism homeostasis.
  • Apoptosis is the primary caspase-dependent cell death pathway.
  • Non-apoptotic programmed cell death mechanisms are increasingly recognized.

Purpose of the Study:

  • To review the multifaceted roles of the p53 tumor suppressor in diverse non-canonical cell death pathways.
  • To elucidate the mechanisms by which p53 influences non-apoptotic cell death.
  • To highlight the context-dependent functions of p53 in cell fate decisions.

Main Methods:

  • Literature review of programmed cell death mechanisms.
  • Analysis of p53's transcriptional and direct regulatory roles.
  • Synthesis of findings across various non-canonical cell death types.

Main Results:

  • p53 modulates caspase-independent apoptosis (CIA), ferroptosis, necroptosis, autophagic cell death, mitotic catastrophe, paraptosis, and pyroptosis.
  • p53's influence is exerted through downstream target regulation and direct protein interactions.
  • p53's function in these pathways is specific to cell type and tissue context.

Conclusions:

  • p53 is a key regulator of multiple non-canonical programmed cell death pathways.
  • Understanding p53's diverse roles is critical for cancer research and therapy.
  • p53 also plays a role in efferocytosis, the clearance of dying cells.
Keywords:
apoptosisautophagycaspase-independent apoptosis (CIA)efferocytosisferroptosismitotic catastrophenecroptosisparaptosispyroptosis

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