[The status of lymphocytes from immunocompetent organs in the development of experimental tumors from 1H-NMR data]

Thymus and lymph node lymphocytes in L-1210 ascite lymphoma, Lewis tumor, 22a hepatoma have been studied by NMR. Lymphocyte 1H-NMR spectra can to a certain extent reflect the state of immune system of an organism, in particular, they can sense both transformation of lymphocytes, and development of several tumors which are not accompanied by transformation of lymphocytes. In the latter case, changes in lymphocyte spectra takes place at terminal stages of carcinogenesis and are less pronounced than at transformation of lymphocytes. NMR spectra parameters can also distinguish between reaction of males and females to tumor formation.