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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Sepsis Incidence: A Population-Based Study.

Lisa Mellhammar1, Sven Wullt1, Åsa Lindberg2

  • 1Department of Clinical Sciences, Division of Infection Medicine, University of Lund , Sweden.

Open Forum Infectious Diseases
|December 13, 2016
PubMed
Summary
This summary is machine-generated.

The incidence of sepsis with organ dysfunction is higher than previously estimated. This study assessed sepsis epidemiology in a Swedish population, finding higher rates than expected across definitions.

Keywords:
SIRS.incidenceqSOFAsepsis

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Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Sepsis is a significant global health concern with limited epidemiological data.
  • Accurate incidence data are crucial for understanding sepsis burden and resource allocation.

Purpose of the Study:

  • To determine the incidence of sepsis with organ dysfunction in a defined population.
  • To compare sepsis incidence using traditional and current definitions (sepsis-3).

Main Methods:

  • Retrospective chart review of adult patients (≥18 years) initiated on intravenous antibiotics in two Swedish regions in 2015.
  • Inclusion criteria focused on new antibiotic treatment to capture incident sepsis cases.
  • Exclusion of patients with pre-existing antibiotic therapy and sepsis.

Main Results:

  • 482 patients were included; 339 had diagnosed infections.
  • Sepsis incidence was 687/100,000 (traditional definition) and 780/100,000 (sepsis-3 definition).
  • A significant number of patients met sepsis criteria under both definitions.

Conclusions:

  • The incidence of sepsis with organ dysfunction is higher than most prior estimates.
  • Population-based studies including all inpatients receiving intravenous antibiotics enable accurate sepsis incidence assessment.