Related Experiment Video

Updated: Mar 10, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

22.3K

MicroRNAs Are Associated with Uremic Toxicity, Cardiovascular Calcification, and Disease

Ziad A Massy, Valérie Metzinger-Le Meuth, Laurent Metzinger

    Contributions to Nephrology
    |December 13, 2016
    PubMed
    Abstract

    Insights

    Specific micro-RNAs (miRNAs) show potential as biomarkers for vascular calcification and cardiovascular disease in chronic kidney disease (CKD) patients. These findings could improve diagnosis and management of CKD complications.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Nephrology

    Background:

    • Vascular calcification is a significant risk factor for cardiovascular complications in chronic kidney disease (CKD).
    • Micro-RNAs (miRNAs) are small noncoding RNAs that regulate gene expression and are potential biomarkers and therapeutic targets.

    Purpose of the Study:

    • To investigate the relevance of cardiovascular-specific miRNAs as biomarkers for CKD, cardiovascular disease, and related complications.
    • To explore the role of specific miRNAs in the pathogenesis of vascular calcification and atherosclerosis in CKD.

    Main Methods:

    • Analysis of miRNA and target gene expression in murine models of CKD and atherosclerosis.
    • Correlation of miRNA levels with established biomarkers of CKD and atherosclerosis (cholesterol, urea, calcium).
    • Measurement of serum miRNA levels in CKD patients, hemodialysis patients, and kidney transplant recipients.

    Main Results:

    • Levels of miR-126, miR-143, miR-145, and miR-223 were modulated during CKD and atherosclerosis in murine models.
    • Serum miRNA levels correlated with classical CKD biomarkers and uremic toxins.
    • Dysregulation of these miRNAs was observed in CKD patients, including those on hemodialysis and transplant recipients.

    Conclusions:

    • miR-126, miR-143, miR-145, and miR-223 are potential biomarkers for vascular calcification and cardiovascular disease associated with CKD.
    • These miRNAs may aid in the diagnosis, monitoring, and management of cardiovascular complications in CKD patients.
    • Further research into these miRNAs could offer new therapeutic strategies for preventing cardiovascular disease in CKD.

    More Related Videos

    A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro11:30

    A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

    Published on: June 2, 2022

    2.6K
    Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

    Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

    Published on: May 31, 2016

    20.5K

    Related Concept Videos

    Chronic Kidney Disease II: Clinical Manifestations01:24

    Chronic Kidney Disease II: Clinical Manifestations

    Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
    864
    Chronic Kidney Disease IV: Nursing Management01:18

    Chronic Kidney Disease IV: Nursing Management

    Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
    518
    Nephrons01:10

    Nephrons

    The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
    8.0K
    Renal Corpuscle01:20

    Renal Corpuscle

    The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
    Glomerulus: Structure and Function
    The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
    8.2K
    Nephrotic Syndrome I : Introduction01:24

    Nephrotic Syndrome I : Introduction

    Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
    796
    Acute Kidney Injury II: Pathophysiology01:29

    Acute Kidney Injury II: Pathophysiology

    Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
    1.5K