Phytochemical overview and medicinal importance of Coffea species from the past until now
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Updated: Mar 10, 2026

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions
Published on: October 2, 2018
Éva Brigitta Patay1, Tímea Bencsik1, Nóra Papp1
1Department of Pharmacognosy, Faculty of Pharmacy, University of Pécs, Rókus 2, Pécs, Hungary.
Abstract:
Coffea (coffee) species are grown in almost all countries along the Equator. Many members of the genus have a large production history and an important role both in the global market and researches. Seeds (Coffeae semen) are successfully used in food, cosmetic, and pharmaceutical industries due to its caffeine and high polyphenol content. Nowadays, the three best-known coffee species are Arabic (Coffea arabica L.), Robusta (Coffea robusta L. Linden), and Liberian coffees (Coffea liberica Hiern.). Even though, many records are available on coffee in scientific literature, wild coffee species like Bengal coffee (Coffea benghalensis Roxb. Ex Schult.) could offer many new opportunities and challenges for phytochemical and medical studies. In this comprehensive summary, we focused on the ethnomedicinal, phytochemical, and medical significance of coffee species up to the present.
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