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Roles of SALL2 in tumorigenesis

Chang K Sung1, Hyungshin Yim2

  • 1Department of Biological and Health Sciences, Texas A&M University-Kingsville, Kingsville, TX, 78363, USA.

Archives of Pharmacal Research
|December 14, 2016
PubMed

Insights

The protein p150Sal2 (product of SALL2) and p53 share tumor-suppressing roles. Loss of SALL2 increases mortality and metastasis, suggesting its potential as a cancer biomarker for early diagnosis and risk prediction.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • p150Sal2 (SALL2) and p53 proteins exhibit shared growth arrest and pro-apoptotic functions.
  • Both proteins induce p21Cip1/Waf1 and BAX, and are targeted by human papilloma virus E6, inhibiting growth arrest.

Purpose of the Study:

  • To review the functions of p150Sal2 in normal and diseased cells.
  • To explore its potential as a cancer biomarker and discuss therapeutic strategies.

Main Methods:

  • Comparative analysis of p53 and SALL2 functions.
  • Examination of SALL2 expression in human serous ovarian carcinoma.
  • Review of existing literature on p150Sal2 roles and therapeutic approaches.

Main Results:

  • Loss of both p53 and Sall2 in mice leads to higher mortality and metastasis rates than p53 single mutants.
  • SALL2 loss is observed in human serous ovarian carcinoma, while normal cells maintain high p150Sal2 levels, indicating a tumor suppressive role.
  • p150Sal2 acts as a transcription factor in glioblastoma, converting differentiated cells into stem-like tumor-propagating cells, highlighting context-dependent functions.

Conclusions:

  • p150Sal2 has significant potential as a novel cancer biomarker for early diagnosis and risk prediction.
  • Its tumor suppressive role in the ovary is supported by expression patterns.
  • The diverse functions of p150Sal2 are tissue and context-dependent, necessitating tailored therapeutic approaches.
Keywords:
BAXGlioblastomaHuman papillomavirusMouse polyomavirusOvarian carcinomap150sal2p21Cip1/Waf1p53

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