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Updated: Mar 10, 2026

The Mechanics of Poro-Elastic Contractile Actomyosin Networks As a Model System of the Cell Cytoskeleton
Published on: March 10, 2023
A case for poroelasticity in skeletal muscle finite element analysis: experiment and modeling
Benjamin B Wheatley1, Gregory M Odegard2, Kenton R Kaufman3
1a Soft Tissue Mechanics Laboratory, Department of Mechanical Engineering , Colorado State University , Fort Collins , CO , USA.
Abstract:
Finite element models of skeletal muscle typically ignore the biphasic nature of the tissue, associating any time dependence with a viscoelastic formulation. In this study, direct experimental measurement of permeability was conducted as a function of specimen orientation and strain. A finite element model was developed to identify how various permeability formulations affect compressive response of the tissue. Experimental and modeling results suggest the assumption of a constant, isotropic permeability is appropriate. A viscoelastic only model differed considerably from a visco-poroelastic model, suggesting the latter is more appropriate for compressive studies.
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