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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
From the molecule to the mole: improving heterogeneous copper catalyzed click chemistry using single molecule
Bowen Wang1, Javier Durantini2, Matthew R Decan2
1Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation (CCRI), University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada. anabel.lanterna@icloud.com titoscaiano@mac.com and State Key Laboratory of Chemical Resource Engineering, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China.
Abstract:
Single molecule spectroscopy (SMS) inspired the optimization of a heterogeneous 'click' catalyst leading to enhanced yields of the Cu-catalyzed reaction of azides with terminal alkynes. Changes in SMS data after optimization confirm the improvements in catalyst performance.

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