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[Relapses in inflammatory myopathies].

Blas J Larrauri1, Diego S Fernández Romero1, Maria Cecilia Juri1

  • 1Unidad de Alergia, Asma e Inmunología Clínica, Buenos Aires, Argentina.

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|December 14, 2016
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Summary
This summary is machine-generated.

Long-term treatment for inflammatory myopathies, including polymyositis and dermatomyositis, achieved remission or partial control in most cycles. However, the condition recurred over time in all patients studied.

Keywords:
dermatomyositisinflammatory myopathypolymiositisrecurrence

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Area of Science:

  • Rheumatology
  • Neurology
  • Immunology

Background:

  • Limited long-term efficacy data exists for inflammatory myopathies treatments.
  • Current studies often rely on cross-sectional analyses.
  • This study focuses on the long-term follow-up of seven patients.

Observation:

  • Seven patients with inflammatory myopathies (5 polymyositis, 2 dermatomyositis) were followed.
  • Treatment efficacy was assessed through treatment cycles, defined by changes in medication.
  • Clinical features, muscle enzyme levels, and treatment responses were monitored.

Findings:

  • Twenty treatment cycles were analyzed.
  • Remission was achieved in 14 cycles (average 139 days).
  • Partial control was achieved in 5 cycles (average 160 days).
  • Treatment failure occurred in 1 cycle.
  • All patients experienced disease recurrence over time.

Implications:

  • Most treatment cycles effectively controlled or induced remission of inflammatory myopathies symptoms.
  • Despite short-term efficacy, long-term management remains challenging due to disease recurrence.
  • Further research into sustained treatment strategies for inflammatory myopathies is warranted.