Immunohistochemical study of cellular response on the intraocular lens surface

This immunohistochemical study was conducted to observe the cellular proliferation on the surface of an intraocular lens (IOL) implanted in the rabbit eye. One week after extracapsular lens extraction followed by posterior chamber lens implantation, the IOL was removed and examined by an indirect immunohistochemical method using anti-macrophage antiserum. Macrophage immunoreactivities were observed on the small round cells, the middle-sized oval cells, the foreign-body giant cells and the fibroblast-like cells attached to the surface of the IOL. Most of the cellular components on the implanted IOL seemed to be macrophages.