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Related Experiment Video

Updated: Mar 10, 2026

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Immunization in patients with inflammatory rheumatic diseases.

Konstantinos Thomas1, Dimitrios Vassilopoulos1

  • 1Joint Rheumatology Program, Clinical Immunology-Rheumatology Unit, 2nd Department of Medicine and Laboratory, National and Kapodistrian University of Athens School of Medicine, Hippokration General Hospital, 114 Vass. Sophias Ave., 115 27, Athens, Greece.

Best Practice & Research. Clinical Rheumatology
|December 15, 2016
PubMed
Summary

Vaccinations are crucial for preventing infections in patients with inflammatory rheumatic diseases, even those on immunosuppressants. This review covers vaccine safety and efficacy, offering guidance for rheumatic patients on various treatments.

Keywords:
BiologicsCorticosteroidsDisease modifying anti-rheumatic drugsHepatitis B virusHerpes zosterHuman papilloma virusInfluenzaPneumococcalVaccines

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Area of Science:

  • Immunology
  • Rheumatology
  • Infectious Diseases

Background:

  • Immunization is a key strategy for preventing infectious diseases in the general and vulnerable populations.
  • Patients with inflammatory rheumatic diseases often receive immunosuppressive therapy, increasing their susceptibility to infections.

Purpose of the Study:

  • To review the safety and efficacy of immunizations in rheumatic patients undergoing immunosuppressive therapy.
  • To provide practical guidance on vaccine administration for this specific patient group.

Main Methods:

  • Literature review of existing data on vaccine safety and efficacy.
  • Analysis of immunizations against various pathogens in patients on conventional immunosuppressives and biologic agents.

Main Results:

  • Vaccination is generally safe and effective in rheumatic patients on immunosuppressants.
  • Specific guidance is needed for optimal vaccine timing and choice in this population.

Conclusions:

  • Vaccination is a vital preventive measure for patients with rheumatic diseases on immunosuppressive treatments.
  • Evidence-based recommendations are essential for ensuring vaccine effectiveness and patient safety.