The curious case of an internal pilot in a multicentre randomised trial-time for a rethink?

Jonathan Alistair Cook1, David John Beard2, Johanna Rosemary Cook3

  • 1Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD UK.

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